Article
Allele-specific expression reveals functional SNPs affecting muscle-related genes in bovine.
Biochimica et biophysica acta. Gene regulatory mechanisms - 1 Nov 2022
Bruscadin Jennifer Jessica, Cardoso Tainã Figueiredo, da Silva Diniz Wellison Jarles, Afonso Juliana, de Souza Marcela Maria, Petrini Juliana, Nascimento Andrade Bruno Gabriel, da Silva Vinicius Henrique, Ferraz José Bento Sterman, Zerlotini Adhemar, Mourão Gerson Barreto, Coutinho Luiz Lehmann, de Almeida Regitano Luciana Correia
Abstract excerpt
Single nucleotide polymorphisms showing allele-specific expression (ASE SNPs) are useful for cis-regulatory variants discovery. Despite this potential, there are expensive costs involved in genome-level ASE analysis for large sample sizes. If different data resolutions are available, genotype imputation can be used to mitigate this limitation. Aiming to increase the power to detect regulatory variants, we used a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.