Article
Modeling allele-specific expression at the gene and SNP levels simultaneously by a Bayesian logistic mixed regression model.
BMC bioinformatics - 28 Oct 2019
Xie Jing, Ji Tieming, Ferreira Marco A R, Li Yahan, Patel Bhaumik N, Rivera Rocio M
Abstract excerpt
BACKGROUND: High-throughput sequencing experiments, which can determine allele origins, have been used to assess genome-wide allele-specific expression. Despite the amount of data generated from high-throughput experiments, statistical methods are often too simplistic to understand the complexity of gene expression. Specifically, existing methods do not test allele-specific expression (ASE) of a gene as a whole...
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