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Allele-specific binding variants causing ChIP-seq peak height of histone modification are not enriched in expression QTL annotations.

Genetics, selection, evolution : GSE - 27 Jun 2024

Ghoreishifar Mohammad, Chamberlain Amanda J, Xiang Ruidong, Prowse-Wilkins Claire P, Lopdell Thomas J, Littlejohn Mathew D, Pryce Jennie E, Goddard Michael E

Abstract excerpt

BACKGROUND: Genome sequence variants affecting complex traits (quantitative trait loci, QTL) are enriched in functional regions of the genome, such as those marked by certain histone modifications. These variants are believed to influence gene expression. However, due to the linkage disequilibrium among nearby variants, pinpointing the precise location of QTL is challenging. We aimed to identify allele-specific...

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Identifiers

PMID: 38937662
DOI: 10.1186/s12711-024-00916-4
PMCID: PMC11212393

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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