Article
Brain hypometabolism in non-demented microtubule-associated protein tau H1 carriers with Parkinson's disease.
Journal of neuroimaging : official journal of the American Society of Neuroimaging - 1 Jan 2000
Gasca-Salas Carmen, Trompeta Clara, López-Aguirre Miguel, Rodríguez Rojas Rafael, Clarimon Jordi, Dols-Icardo Oriol, El Bounasri Shaimaa, Guida Pasqualina, Mata-Marín David, Hernández-Fernández Frida, Marras Connie, García-Cañamaque Lina, Plaza de Las Heras Isabel, Obeso Ignacio, Vela Lydia, Fernández-Rodríguez Beatriz
Abstract excerpt
BACKGROUND AND PURPOSE: The microtubule-associated protein tau (MAPT) H1 homozygosity (H1/H1 haplotype) is a genetic risk factor for neurodegenerative diseases, such as Parkinson's disease (PD). MAPT H1 homozygosity has been associated with conversion to PD; however, results are conflicting since some studies did not find a strong influence. Cortical hypometabolism is associated with cognitive impairment in PD....
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