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Article

APOE and MAPT Are Associated With Dementia in Neuropathologically Confirmed Parkinson's Disease

5 Feb 2021

Abstract excerpt

Introduction: Cognitive decline and dementia are common and debilitating non-motor phenotypic features of Parkinson's disease with a variable severity and time of onset. Common genetic variation of the Apolipoprotein E ( APOE ) and micro-tubule associated protein tau ( MAPT ) loci have been linked to cognitive decline and dementia in Parkinson's disease, although studies have yielded mixed results. To further...

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PMID: 33613437
DOI: 10.3389/fneur.2021.631145

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