Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms in dopamine-associated genes and cognitive decline in Parkinson's disease.

Acta neurologica Scandinavica - 1 Jan 2018

Bäckström D, Eriksson Domellöf M, Granåsen G, Linder J, Mayans S, Elgh E, Zetterberg H, Blennow K, Forsgren L

Abstract excerpt

OBJECTIVES: Cognitive decline is common in Parkinson's disease (PD), but the underlying mechanisms for this complication are incompletely understood. Genotypes affecting dopamine transmission may be of importance. This study investigates whether genotypes associated with reduced prefrontal dopaminergic tone and/or reduced dopamine D2-receptor availability (Catechol-O-methyltransferase [COMT] Val158 Met genotype...

Topics

Join the communities discussing this publication.

Aged
Catechol O-Methyltransferase
Cognitive Dysfunction
Genotype
Neuropsychological Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Parkinson Disease

Polymorphism, Single Nucleotide

Receptors, Dopamine D2

Source

Open in PubMed Open full text

Identifiers

PMID: 28869277
DOI: 10.1111/ane.12812
PMCID: PMC5763317

Genes

DRD2
COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms in dopamine-associated genes and cognitive decline in Parkinson's disease.PMID 28869277Read ↗

Genetic influences on cognitive decline in Parkinson's disease.Semantic proximity Read ↗

Catechol-O-methyltransferase val158met and cognitive function in Parkinson's disease.Semantic proximity Read ↗

Genetic factors influencing frontostriatal dysfunction and the development of dementia in Parkinson's disease.Semantic proximity Read ↗

APOE, MAPT, and COMT and Parkinson's Disease Susceptibility and Cognitive Symptom Progression.Semantic proximity Read ↗

The impact of common genetic variants in cognitive decline in the first seven years of Parkinson's disease: A longitudinal observational study.Semantic proximity Read ↗

Vitamin D receptor gene polymorphisms and cognitive decline in Parkinson's disease.Semantic proximity Read ↗

Catechol-O-methyltransferase Val158Met polymorphism influences prefrontal executive function in early Parkinson's disease.Semantic proximity Read ↗

Genetic risk factors for cognitive decline in Parkinson's disease: a review of the literature.Semantic proximity Read ↗

Mild Behavioral Impairment in Parkinson's Disease: An Updated Review on the Clinical, Genetic, Neuroanatomical, and Pathophysiological Aspects.Semantic proximity Read ↗

APOE, MAPT, and SNCA genes and cognitive performance in Parkinson disease.Semantic proximity Read ↗

Cognition among individuals along a spectrum of increased risk for Parkinson's disease.Semantic proximity Read ↗

The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.