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Article

Association between MAPT haplotype and memory function in patients with Parkinson's disease and healthy aging individuals.

Neurobiology of aging - 1 Mar 2015

Winder-Rhodes Sophie E, Hampshire Adam, Rowe James B, Peelle Jonathan E, Robbins Trevor W, Owen Adrian M, Barker Roger A

Abstract excerpt

Genetic variation is associated with differences in the function of the brain as well as its susceptibility to disease. The common H1 haplotypic variant of the microtubule-associated protein tau gene (MAPT) has been related to an increased risk for Parkinson's disease (PD). Furthermore, among PD patients, H1 homozygotes have an accelerated progression to dementia. We investigated the neurocognitive correlates of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25577413
DOI: 10.1016/j.neurobiolaging.2014.12.006
PMCID: PMC4353560

Genes

MAPT

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Related research

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Click a neighbor to travelStep 1 · 12 closest

Association between MAPT haplotype and memory function in patients with Parkinson's disease and healthy aging individuals.PMID 25577413Read ↗

Brain hypometabolism in non-demented microtubule-associated protein tau H1 carriers with Parkinson's disease.Semantic proximity Read ↗

H1 haplotype of the MAPT gene is associated with lower regional gray matter volume in healthy carriers.Semantic proximity Read ↗

The Role of MAPT Haplotype H2 and Isoform 1N/4R in Parkinsonism of Older Adults.Semantic proximity Read ↗

MAPT H1 haplotype is associated with enhanced α-synuclein deposition in dementia with Lewy bodies.Semantic proximity Read ↗

Association of the tau haplotype H2 with age at onset and functional alterations of glucose utilization in frontotemporal dementia.Semantic proximity Read ↗

Tau haplotype influences cerebral perfusion pattern in frontotemporal lobar degeneration and related disorders.Semantic proximity Read ↗

Association analysis of MAPT H1 haplotype and subhaplotypes in Parkinson's disease.Semantic proximity Read ↗

Tau haplotypes regulate transcription and are associated with Parkinson's disease.Semantic proximity Read ↗

Different MAPT haplotypes influence expression of total MAPT in postmortem brain tissue.Semantic proximity Read ↗

Role of ethnicity on the association of MAPT H1 haplotypes and subhaplotypes in Parkinson's disease.Semantic proximity Read ↗

The H1c haplotype at the MAPT locus is associated with Alzheimer's disease.Semantic proximity Read ↗

The H2 MAPT haplotype is associated with familial frontotemporal dementia.Semantic proximity Read ↗

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