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Article

Association of the tau haplotype H2 with age at onset and functional alterations of glucose utilization in frontotemporal dementia.

The American journal of psychiatry - 1 Oct 2007

Laws Simon M, Perneczky Robert, Drzezga Alexander, Diehl-Schmid Janine, Ibach Bernd, Bäuml Josef, Eisele Tamara, Förstl Hans, Kurz Alexander, Riemenschneider Matthias

Abstract excerpt

OBJECTIVE: The microtubule-associated protein tau gene (MAPT) contains two extended haplotypes, H1 and H2, which have been linked with sporadic tauopathies. However, there is little evidence as to how these haplotypes may influence the clinical features of the disease. The aim of this study was t...

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Source

Identifiers

PMID: 17898350
DOI: 10.1176/appi.ajp.2007.06091456

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17898350-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Association of the tau haplotype H2 with age at onset and functional alterations of glucose utilization in frontotemporal dementia.PMID 17898350Read ↗

Association between tau H2 haplotype and age at onset in frontotemporal dementia.Semantic proximity Read ↗

The H2 MAPT haplotype is associated with familial frontotemporal dementia.Semantic proximity Read ↗

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Association between the extended tau haplotype and frontotemporal dementia.Semantic proximity Read ↗

The MAPT H1 Haplotype Is a Risk Factor for Alzheimer’s Disease in APOE ε4 Non-carriersSemantic proximity Read ↗

H1 haplotype of the MAPT gene is associated with lower regional gray matter volume in healthy carriers.Semantic proximity Read ↗

Tau haplotype influences cerebral perfusion pattern in frontotemporal lobar degeneration and related disorders.Semantic proximity Read ↗

The Role of MAPT Haplotype H2 and Isoform 1N/4R in Parkinsonism of Older Adults.Semantic proximity Read ↗

Association of MAPT haplotypes with Alzheimer’s disease risk and MAPT brain gene expression levelsSemantic proximity Read ↗

The MAPT H1 haplotype is associated with tangle-predominant dementia.Semantic proximity Read ↗

MAPT Haplotype Variation and Alzheimer's Disease Risk: A Narrative Review with Focus on the Jordanian Population.Semantic proximity Read ↗

The role of MAPT sequence variation in mechanisms of disease susceptibility.Semantic proximity Read ↗

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