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When special populations intersect with drug-drug interactions: Application of physiologically-based pharmacokinetic modeling in pregnant populations.

Biopharmaceutics & drug disposition - 1 Apr 2021

Sychterz Caroline, Galetin Aleksandra, Taskar Kunal S

Abstract excerpt

Pregnancy results in significant physiological changes that vary across trimesters and into the postpartum period, and may result in altered disposition of endogenous substances and drug pharmacokinetics. Pregnancy represents a unique special population where physiologically-based pharmacokinetic modeling (PBPK) is well suited to mechanistically explore pharmacokinetics and dosing paradigms without subjecting...

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PMID: 33759451
DOI: 10.1002/bdd.2272

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