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Intra- vs. Interhost Evolution of SARS-CoV-2 Driven by Uncorrelated Selection-The Evolution Thwarted.

Molecular biology and evolution - 1 Sept 2023

Hou Mei, Shi Jingrong, Gong Zanke, Wen Haijun, Lan Yun, Deng Xizi, Fan Qinghong, Li Jiaojiao, Jiang Mengling, Tang Xiaoping, Wu Chung-I, Li Feng, Ruan Yongsen

Abstract excerpt

In viral evolution, a new mutation has to proliferate within the host (Stage I) in order to be transmitted and then compete in the host population (Stage II). We now analyze the intrahost single nucleotide variants (iSNVs) in a set of 79 SARS-CoV-2 infected patients with most transmissions tracked. Here, every mutation has two measures: 1) iSNV frequency within each individual host in Stage I; 2) occurrence among...

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Identifiers

PMID: 37707487
DOI: 10.1093/molbev/msad204
PMCID: PMC10521905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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