Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Causes and Consequences of Purifying Selection on SARS-CoV-2.

Genome biology and evolution - 1 Oct 2021

Morales Atahualpa Castillo, Rice Alan M, Ho Alexander T, Mordstein Christine, Mühlhausen Stefanie, Watson Samir, Cano Laura, Young Bethan, Kudla Grzegorz, Hurst Laurence D

Abstract excerpt

Owing to a lag between a deleterious mutation's appearance and its selective removal, gold-standard methods for mutation rate estimation assume no meaningful loss of mutations between parents and offspring. Indeed, from analysis of closely related lineages, in SARS-CoV-2, the Ka/Ks ratio was previously estimated as 1.008, suggesting no within-host selection. By contrast, we find a higher number of observed SNPs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Codon, Nonsense
Share to Codon Usage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to COVID-19

Share to Mutation, Missense

Share to Mutation Rate

Share to SARS-CoV-2

Share to Selection, Genetic

Share to Silent Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 34427640
DOI: 10.1093/gbe/evab196
PMCID: PMC8504154

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Causes and Consequences of Purifying Selection on SARS-CoV-2.PMID 34427640Read ↗

Ongoing natural selection drives the evolution of SARS-CoV-2 genomesSemantic proximity Read ↗

The mutation rate of SARS-CoV-2 is highly variable between sites and is influenced by sequence context, genomic region, and RNA structureSemantic proximity Read ↗

Two-step fitness selection for intra-host variations in SARS-CoV-2.Semantic proximity Read ↗

Ongoing Positive Selection Drives the Evolution of SARS-CoV-2 GenomesSemantic proximity Read ↗

SARS-CoV-2 genome evolution exposes early human adaptationsSemantic proximity Read ↗

Properties and Mechanisms of Deletions, Insertions, and Substitutions in the Evolutionary History of SARS-CoV-2.Semantic proximity Read ↗

<strong>Attenuation and Degeneration of SARS-CoV-2 Despite of Adaptive Evolution</strong>Semantic proximity Read ↗

Purifying selection and adaptive evolution proximate to the zoonosis of SARS-CoV-1 and SARS-CoV-2Semantic proximity Read ↗

Evidence for selection on SARS-CoV-2 RNA translation revealed by the evolutionary dynamics of mutations in UTRs and CDSs.Semantic proximity Read ↗

Intra- vs. Interhost Evolution of SARS-CoV-2 Driven by Uncorrelated Selection-The Evolution Thwarted.Semantic proximity Read ↗

Mutational signatures and heterogeneous host response revealed via large-scale characterization of SARS-CoV-2 genomic diversitySemantic proximity Read ↗

Within-host evolution of SARS-CoV-2: how often are <i>de novo</i> mutations transmitted?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.