Article
Two-step fitness selection for intra-host variations in SARS-CoV-2.
Cell reports - 11 Jan 2022
Li Jiarui, Du Pengcheng, Yang Lijiang, Zhang Ju, Song Chuan, Chen Danying, Song Yangzi, Ding Nan, Hua Mingxi, Han Kai, Song Rui, Xie Wen, Chen Zhihai, Wang Xianbo, Liu Jingyuan, Xu Yanli, Gao Guiju, Wang Qi, Pu Lin, Di Lin, Li Jie, Yue Jinglin, Han Junyan, Zhao Xuesen, Yan Yonghong, Yu Fengting, Wu Angela R, Zhang Fujie, Gao Yi Qin, Huang Yanyi, Wang Jianbin, Zeng Hui, Chen Chen
Abstract excerpt
Spontaneous mutations introduce uncertainty into coronavirus disease 2019 (COVID-19) control procedures and vaccine development. Here, we perform a spatiotemporal analysis on intra-host single-nucleotide variants (iSNVs) in 402 clinical samples from 170 affected individuals, which reveals an increase in genetic diversity over time after symptom onset in individuals. Nonsynonymous mutations are overrepresented in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.