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Article

Crosstalk between DNA methylation and hypoxia in acute myeloid leukaemia

13 Sept 2023

Abstract excerpt

BACKGROUND: Acute myeloid leukaemia (AML) is a deadly disease characterised by the uncontrolled proliferation of immature myeloid cells within the bone marrow. Altered regulation of DNA methylation is an important epigenetic driver of AML, where the hypoxic bone marrow microenvironment can help facilitate leukaemogenesis. Thus, interactions between epigenetic regulation and hypoxia signalling will have important...

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Share to Acute Myeloid Leukemia Research
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PMID: 37705055
DOI: 10.1186/s13148-023-01566-x

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