Aberrant DNA Methylation in Acute Myeloid Leukemia and Its Clinical Implications

doi:10.3390/ijms20184576

Article

Aberrant DNA Methylation in Acute Myeloid Leukemia and Its Clinical Implications

16 Sept 2019

Abstract excerpt

Acute myeloid leukemia (AML) is a heterogeneous disease that is characterized by distinct cytogenetic or genetic abnormalities. Recent discoveries in cancer epigenetics demonstrated a critical role of epigenetic dysregulation in AML pathogenesis. Unlike genetic alterations, the reversible nature of epigenetic modifications is therapeutically attractive in cancer therapy. DNA methylation is an epigenetic...

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