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Hypoxia and Hypoxia-Inducible Factors in Leukemias

26 Feb 2016

Abstract excerpt

Despite huge improvements in the treatment of leukemia, the percentage of patients suffering relapse still remains significant. Relapse most often results from a small number of leukemic stem cells (LSCs) within the bone marrow, which are able to self-renew, and therefore reestablish the full tumor. The marrow microenvironment contributes considerably in supporting the protection and development of leukemic...

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PMID: 26955619
DOI: 10.3389/fonc.2016.00041

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