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Mechanisms of myeloid leukemogenesis: Current perspectives and therapeutic objectives

2 Aug 2022

Abstract excerpt

Acute myeloid leukemia (AML) is a heterogeneous hematopoietic neoplasm which results in clonal proliferation of abnormally differentiated hematopoietic cells. In this review, mechanisms contributing to myeloid leukemogenesis are summarized, highlighting aberrations of epigenetics, transcription factors, signal transduction, cell cycling, and the bone marrow microenvironment. The mechanisms contributing to AML are...

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PMID: 35989139
DOI: 10.1016/j.blre.2022.100996

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