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Article

Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes

23 Aug 2018

Abstract excerpt

Abstract Myelodysplastic syndromes (MDS) are heterogeneous hematopoietic disorders that are incurable with conventional therapy. Their incidence is increasing with global population aging. Although many genetic, epigenetic, splicing, and metabolic aberrations have been identified in patients with MDS, their clinical features are quite similar. Here, we show that hypoxia-independent activation of hypoxia-inducible...

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PMID: 30139811
DOI: 10.1158/2159-8290.cd-17-1203

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