Article
The protective association of HLA-C*12:02 and HLA-DQB1*06:01 with severe acute hepatitis of unknown origin in the Japanese population.
HLA - 1 Jan 2024
Okamoto Tatsuya, Okajima Hideaki, Ogawa Eri, Kadohisa Masashi, Yamamoto Miki, Uebayashi Elena Yukie, Yurugi Kimiko, Ito Takashi, Hatano Etsuro
Abstract excerpt
Global surveillance has been conducted to elucidate the pathogenesis of acute hepatitis of unknown origin (AHUO), However, the factors associated with the aggravation of this serious disease are unclear. Therefore, we conducted a HLA association study to identify HLA alleles or haplotypes predisposing or protective against Japanese AHUO. The HLA 5 locus (HLA-A, HLA-B, C, DRB1, and DQB1) 4-digit genotyping results...
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