Article
HLA-DRB1 and DQB1 alleles in Japanese type 1 autoimmune hepatitis: The predisposing role of the DR4/DR8 heterozygous genotype.
PloS one - 1 Jan 2017
Oka Shomi, Furukawa Hiroshi, Yasunami Michio, Kawasaki Aya, Nakamura Hitomi, Nakamura Minoru, Komori Atsumasa, Abiru Seigo, Nagaoka Shinya, Hashimoto Satoru, Naganuma Atsushi, Naeshiro Noriaki, Yoshizawa Kaname, Yamashita Haruhiro, Ario Keisuke, Ohta Hajime, Sakai Hironori, Yabuuchi Iwao, Takahashi Atsushi, Abe Kazumichi, Yatsuhashi Hiroshi, Tohma Shigeto, Ohira Hiromasa, Tsuchiya Naoyuki, Migita Kiyoshi
Abstract excerpt
OBJECTIVE: Autoimmune hepatitis (AIH) is a chronic progressive liver disease. AIH is composed predominantly of type 1 in Japanese populations. The genetic and environmental factors are associated with the pathogenesis of AIH. HLA-DRB1*03:01 and *04:01 are associated with type 1 AIH in European and *04:05 in Japanese populations. Here, we conducted an HLA association study in order to find HLA alleles or...
Topics
- Adult
- Alleles
- Female
- Genetic Predisposition to Disease
- Genotype
- HLA-DQ beta-Chains
- HLA-DRB1 Chains
- Haplotypes
- Hepatitis, Autoimmune