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HLA-DQA101:03 and DQB106:01 are risk factors for severe COVID-19 pneumonia.

HLA - 1 Jul 2024

Tanaka Katsushi, Meguro Akira, Hara Yu, Endo Lisa, Izawa Ami, Muraoka Suguru, Kaneko Ayami, Somekawa Kohei, Hirata Momo, Otsu Yukiko, Matsumoto Hiromi, Nagasawa Ryo, Kubo Sosuke, Murohashi Kota, Aoki Ayako, Fujii Hiroaki, Watanabe Keisuke, Horita Nobuyuki, Kato Hideaki, Kobayashi Nobuaki, Takeuchi Ichiro, Nakajima Atsushi, Inoko Hidetoshi, Mizuki Nobuhisa, Kaneko Takeshi

Abstract excerpt

The clinical spectrum of COVID-19 includes a wide range of manifestations, from mild symptoms to severe pneumonia. HLA system plays a pivotal role in immune responses to infectious diseases. The purpose of our study was to investigate the association between HLA and COVID-19 severity in a Japanese population. The study included 209 Japanese COVID-19 patients aged ≥20 years. Saliva samples were collected and used...

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PMID: 39041300
DOI: 10.1111/tan.15609

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