Article
A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population.
Human molecular genetics - 1 Oct 2011
Mbarek Hamdi, Ochi Hidenori, Urabe Yuji, Kumar Vinod, Kubo Michiaki, Hosono Naoya, Takahashi Atsushi, Kamatani Yoichiro, Miki Daiki, Abe Hiromi, Tsunoda Tatsuhiko, Kamatani Naoyuki, Chayama Kazuaki, Nakamura Yusuke, Matsuda Koichi
Abstract excerpt
Hepatitis B virus (HBV) infection is a major health issue worldwide which may lead to hepatic dysfunction, liver cirrhosis and hepatocellular carcinoma. To identify host genetic factors that are associated with chronic hepatitis B (CHB) susceptibility, we previously conducted a two-stage genome-wide association study (GWAS) and identified the association of HLA-DP variants with CHB in Asians; however, only 179...
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