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Article

Principal contribution of HLA-DQ alleles, DQB106:04 and DQB103:01, to disease resistance against primary biliary cholangitis in a Japanese population.

Scientific reports - 11 Sept 2017

Yasunami Michio, Nakamura Hitomi, Tokunaga Katsushi, Kawashima Minae, Nishida Nao, Hitomi Yuki, Nakamura Minoru

Abstract excerpt

Identification of the primary allele(s) in HLA class II associated diseases remains challenging because of a tight linkage between alleles of HLA-DR and -DQ loci. In the present study, we determined the genotypes of seven HLA loci (HLA-A, -B, -DRB1, -DQA1, -DQB1, -DPA1 and -DPB1) for 1200 Japanese patients with primary biliary cholangitis and 1196 controls. Observation of recombination derivatives facilitated an...

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Identifiers

PMID: 28894202
DOI: 10.1038/s41598-017-11148-6
PMCID: PMC5593890

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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