Article
Novel HLA allele associations with susceptibility, staging, symptomatic state, autoimmune hepatitis and hepatocellular carcinoma events for primary biliary cholangitis in the Japanese population.
Frontiers in immunology - 1 Jan 2023
Khor Seik-Soon, Ueno Kazuko, Nishida Nao, Kawashima Minae, Kawai Yosuke, Aiba Yoshihiro, Hitomi Yuki, Nagasaki Masao, Nakamura Minoru, Tokunaga Katsushi
Abstract excerpt
Primary biliary cholangitis (PBC) is a rare autoimmune disease with a clear predisposition for human leukocyte antigen (HLA)-DR/DQ-associated loss of immune tolerance for the E2 component of the pyruvate dehydrogenase complex. Three-field-resolution HLA imputation of 1,670 Japanese PBC patients and 2,328 healthy controls was conducted using Japanese population-specific HLA reference panels. Eighteen previously...
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