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Brain morphology mediating the effect of genetic risk variants on Alzheimer’s disease

2024-01-13

Abstract excerpt

<h4>INTRODUCTION</h4> Late-onset Alzheimer’s disease (LOAD) has been associated with alterations in the morphology of multiple brain structures and it is likely that disease mechanisms differ between brain regions. Coupling genetic determinants of LOAD with measures of brain morphology could localize and identify primary causal neurobiological pathways. <h4>METHODS</h4> Mediation and Mendelian randomization (MR) a...

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Literature Corpus work
d6c3bdb7-67b4-5e02-ae02-02b8a078bb84
DOI
10.1101/2024.01.12.24301205
Open publication

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Brain morphology mediating the effect of genetic risk variants on Alzheimer’s diseaseDOI 10.1101/2024.01.12.24301205
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