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Article

Multiple mechanisms of self-association of chemokine receptors CXCR4 and CCR5 demonstrated by deep mutagenesis.

The Journal of biological chemistry - 1 Oct 2023

Gill Kevin S, Mehta Kritika, Heredia Jeremiah D, Krishnamurthy Vishnu V, Zhang Kai, Procko Erik

Abstract excerpt

Chemokine receptors are members of the rhodopsin-like class A GPCRs whose signaling through G proteins drives the directional movement of cells in response to a chemokine gradient. Chemokine receptors CXCR4 and CCR5 have been extensively studied due to their roles in leukocyte development and inflammation and their status as coreceptors for HIV-1 infection, among other roles. Both receptors form dimers or...

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Identifiers

PMID: 37690681
DOI: 10.1016/j.jbc.2023.105229
PMCID: PMC10551899

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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