Article
Separating Actin-Dependent Chemokine Receptor Nanoclustering from Dimerization Indicates a Role for Clustering in CXCR4 Signaling and Function.
Molecular cell - 5 Apr 2018
Martínez-Muñoz Laura, Rodríguez-Frade José Miguel, Barroso Rubén, Sorzano Carlos Óscar S, Torreño-Pina Juan A, Santiago César A, Manzo Carlo, Lucas Pilar, García-Cuesta Eva M, Gutierrez Enric, Barrio Laura, Vargas Javier, Cascio Graciela, Carrasco Yolanda R, Sánchez-Madrid Francisco, García-Parajo María F, Mellado Mario
Abstract excerpt
A current challenge in cell motility studies is to understand the molecular and physical mechanisms that govern chemokine receptor nanoscale organization at the cell membrane, and their influence on cell response. Using single-particle tracking and super-resolution microscopy, we found that the chemokine receptor CXCR4 forms basal nanoclusters in resting T cells, whose extent, dynamics, and signaling strength are...
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