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Article

Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices.

Proceedings of the National Academy of Sciences of the United States of America - 30 Aug 2016

Wescott Melanie P, Kufareva Irina, Paes Cheryl, Goodman Jason R, Thaker Yana, Puffer Bridget A, Berdougo Eli, Rucker Joseph B, Handel Tracy M, Doranz Benjamin J

Abstract excerpt

The atomic-level mechanisms by which G protein-coupled receptors (GPCRs) transmit extracellular ligand binding events through their transmembrane helices to activate intracellular G proteins remain unclear. Using a comprehensive library of mutations covering all 352 residues of the GPCR CXC chemokine receptor 4 (CXCR4), we identified 41 amino acids that are required for signaling induced by the chemokine ligand...

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Share to Binding Sites
Share to Chemokine CXCL12

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Sequence Homology, Amino Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 27543332
DOI: 10.1073/pnas.1601278113
PMCID: PMC5024644

Genes

CXCR4
CXCL12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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