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Article

FLIM-FRET-Based Structural Characterization of a Class-A GPCR Dimer in the Cell Membrane.

Journal of molecular biology - 24 Jul 2020

Yang Ju, Gong Zhou, Lu Yun-Bi, Xu Chan-Juan, Wei Tao-Feng, Yang Meng-Shi, Zhan Tian-Wei, Yang Yu-Hong, Lin Li, Liu Jianfeng, Tang Chun, Zhang Wei-Ping

Abstract excerpt

Class-A G protein-coupled receptors (GPCRs) are known to homo-dimerize in the membrane. Yet, methods to characterize the structure of GPCR dimer in the native environment are lacking. Accordingly, the molecular basis and functional relevance of the class-A GPCR dimerization remain unclear. Here, we present the dimeric structural model of GPR17 in the cell membrane. The dimer mainly involves transmembrane helix 5...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32553728
DOI: 10.1016/j.jmb.2020.06.009

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