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Article

Receptor conformation and constitutive activity in CCR5 chemokine receptor function and HIV infection.

Advances in pharmacology (San Diego, Calif.) - 1 Jan 2014

Flanagan Colleen A

Abstract excerpt

The CCR5 chemokine receptor mediates the effects of proinflammatory β-chemokines that stimulate chemotaxis, activation, and proliferation of macrophages and T cells. CCR5 is also the major coreceptor that mediates HIV infection in combination with CD4. Chemokine agonists of CCR5 stimulate the activation of cellular calcium and protein kinase signaling pathways that depend on the activation of Gαi and probably...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24931198
DOI: 10.1016/B978-0-12-417197-8.00008-0

Genes

CCR5
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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