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Article

Conservation of unfavorable sequence motifs that contribute to the chemokine quaternary state.

Biochemistry - 7 Oct 2008

Kagiampakis Ioannis, Jin Hongjun, Kim Sinae, Vannucci Marina, LiWang Patricia J, Tsai Jerry

Abstract excerpt

In the chemokine family, we characterize two examples of evolutionarily conserved unfavorable sequence motifs that affect quaternary structure. In contrast to the straightforward action of favorable sequences, these unfavorable motifs produce interactions disfavoring one outcome to indirectly promote another one but should not be confused with the broad sampling produced by negative selection and/or design. To...

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Source

Identifiers

PMID: 18781776
DOI: 10.1021/bi702288a

Genes

CXCL8
CCL2
CCL4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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