Article
Oncogenic BRAF noncanonically promotes tumor metastasis by mediating VASP phosphorylation and filopodia formation.
Oncogene - 1 Oct 2023
Pan Wenting, Tian Yihao, Zheng Qian, Yang Zelin, Qiang Yulong, Zhang Zun, Zhang Nan, Xiong Jie, Zhu Xin, Wei Lei, Li Feng
Abstract excerpt
BRAF is frequently mutated in various cancer types and contributes to tumorigenesis and metastasis. As an important switch in RAS signaling pathway, BRAF typically enables the activation of MEK and ERK, and its mutation significantly promotes metastasis. However, whether BRAF could stimulate metastasis via a distinct manner is still unknown. Herein, we found that a portion of the BRAF protein localized at the...
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