Article
Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia.
Proceedings of the National Academy of Sciences of the United States of America - 7 Feb 2012
Bottos Alessia, Martini Miriam, Di Nicolantonio Federica, Comunanza Valentina, Maione Federica, Minassi Alberto, Appendino Giovanni, Bussolino Federico, Bardelli Alberto
Abstract excerpt
Carcinomas are comprised of transformed epithelial cells that are supported in their growth by a dedicated neovasculature. How the genetic milieu of the epithelial compartment influences tumor angiogenesis is largely unexplored. Drugs targeted to mutant cancer genes may act not only on tumor cells but also, directly or indirectly, on the surrounding stroma. We investigated the role of the BRAF(V600E) oncogene in...
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