Article

Cooperative function of oncogenic MAPK signaling and the loss of Pten for melanoma migration through the formation of lamellipodia

2023-02-23

Abstract excerpt

<title>Abstract</title> <p>The combination of oncogenes and tumor suppressors overcomes selective pressure from host immune systems for cancer development; however, it is still unknown whether their combination plays a critical role in cancer metastasis. We herein investigated whether genetic combinations affected cell migration ability by establishing the immortalized melanocytes, melan-a cells, with an oncogene...

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Literature Corpus work: 9e443e94-e6ba-5791-90a4-dbd3678186c5
DOI: 10.21203/rs.3.rs-2572171/v1

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