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Article

miR-550a-3-5p acts as a tumor suppressor and reverses BRAF inhibitor resistance through the direct targeting of YAP.

Cell death & disease - 29 May 2018

Choe Min Ho, Yoon Yina, Kim Joon, Hwang Sang-Gu, Han Young-Hoon, Kim Jae-Sung

Abstract excerpt

Although evidence has emerged to suggest that YAP overexpression is a crucial factor for tumor progression and resistance to targeted drugs in multiple cancers, the miRNA-mediated YAP regulation is still unclear. Here we show that the novel miR-550a-3-5p acts as a tumor suppressor and reverses BRAF inhibitor resistance through the direct targeting of YAP. Our data showed that the miR-550a-3-5p suppressed cell...

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Source

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Identifiers

PMID: 29844307
DOI: 10.1038/s41419-018-0698-3
PMCID: PMC5974323

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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