Article
Autophosphorylation on S614 inhibits the activity and the transforming potential of BRAF.
Cellular signalling - 1 Sept 2016
Dernayka Layal, Rauch Nora, Jarboui Mohamed-Ali, Zebisch Armin, Texier Yves, Horn Nicola, Romano David, Gloeckner Christian Johannes, Kriegsheim Alex von, Ueffing Marius, Kolch Walter, Boldt Karsten
Abstract excerpt
The BRAF proto-oncogene serine/threonine-protein kinase, known as BRAF, belongs to the RAF kinase family. It regulates the MAPK/ERK signalling pathway affecting several cellular processes such as growth, survival, differentiation, and cellular transformation. BRAF is mutated in ~8% of all human cancers with the V600E mutation constituting ~90% of mutations. Here, we have used quantitative mass spectrometry to map...
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