Article

Oncogenic BRAF noncanonically promotes tumor metastasis by mediating VASP phosphorylation and filopodia formation

2023-05-05

Abstract excerpt

<title>Abstract</title> <p>BRAF is frequently mutated in various cancer types and contributes to tumorigenesis and metastasis. As an important switch in RAS signalling pathway, BRAF typically enables the activation of MEK and ERK, and its mutation significantly promotes metastasis. However, whether BRAF could stimulate metastasis in a MEK/ERK signalling-independent manner is still unknown. Herein, we found that a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 71f3716a-fb3d-5adf-9055-fa0c5f067361
DOI: 10.21203/rs.3.rs-2860088/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Oncogenic BRAF noncanonically promotes tumor metastasis by mediating VASP phosphorylation and filopodia formationDOI 10.21203/rs.3.rs-2860088/v1Read

Oncogenic BRAF noncanonically promotes tumor metastasis by mediating VASP phosphorylation and filopodia formation.Semantic proximity Read

Tumorigenesis driven by the BRAF <sup>V600E</sup> oncoprotein requires secondary mutations that overcome its feedback inhibition of migration and invasionSemantic proximity Read

Emerging BRAF Mutations in Cancer Progression and Their Possible Effects on Transcriptional Networks.Semantic proximity Read

Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia.Semantic proximity Read

[vestigation of molecular factors determining BRAF-inhibitor sensitivity in solid tumors].Semantic proximity Read

Oncogenic BRAF-Mediated Melanoma Cell InvasionSemantic proximity Read

Autophosphorylation on S614 inhibits the activity and the transforming potential of BRAF.Semantic proximity Read

POU4F1 promotes the resistance of melanoma to BRAF inhibitors through MEK/ERK pathway activation and MITF up-regulationSemantic proximity Read

Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration.Semantic proximity Read

Cooperative function of oncogenic MAPK signaling and the loss of Pten for melanoma migration through the formation of lamellipodiaSemantic proximity Read

BRAF has a kinase-independent role in MAPK signaling.Semantic proximity Read

BRAFV600E dictates cell survival via c-Myc-dependent induction of Skp2 in human melanoma.Semantic proximity Read