Vitamin B 6 is governed by the local compartmentalization of metabolic enzymes during growth

Abstract excerpt

Vitamin B 6 is a vital micronutrient across cell types and tissues, and dysregulated B 6 levels contribute to human disease. Despite its importance, how B 6 vitamer levels are regulated is not well understood. Here, we provide evidence that B 6 dynamics are rapidly tuned by precise compartmentation of pyridoxal kinase (PDXK), the rate-limiting B 6 enzyme. We show that canonical Wnt rapidly led to the accumulation...

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