Article

Renal Coenzyme A (CoA) Production from VB5 Fuels Stem Cell Proliferation and Tumor Growth

2025-08-11

Abstract excerpt

Coenzyme A (CoA), derived from Vitamin B5 (VB5; also called pantothenate), is essential for lipid metabolism, energy production, and cell proliferation. While the intracellular functions of CoA are well-characterized, much less is known about its tissue-specific regulation and systemic physiological roles. Here, using Drosophila melanogaster , we uncover a gut-renal circuit in which dietary VB5 fuels CoA biosynth...

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Literature Corpus work: 46f16bfa-5901-5b20-9679-e1411a3425a2
DOI: 10.1101/2025.08.08.669325

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