Article

Pyridoxal kinase (PDXK) facilitates CRC progression by releasing beta-catenin from the GSK-3β destruction complex

2023-11-01

Abstract excerpt

Studies have suggested a close association between hyperactivation of the catenin beta 1 gene (CTNNB1) and the occurrence and progression of colorectal cancer (CRC). Here, we report that Pyridoxal kinase (PDXK) promotes the development of colorectal cancer through Wnt signaling pathway. The expression of PDXK is elevated in CRC patients and is associated with an unfavourable prognosis. Genetic depletion of PDXK si...

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Literature Corpus work: c51dbbf7-753c-5a72-96e1-159328d1fae3
DOI: 10.21203/rs.3.rs-3505983/v1

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