Article
Proteolytic processing of secretory pathway kinase Fam20C by site-1 protease promotes biomineralization.
Proceedings of the National Academy of Sciences of the United States of America - 10 Aug 2021
Chen Xinxin, Zhang Jianchao, Liu Pulan, Wei Yangyang, Wang Xi'e, Xiao Junyu, Wang Chih-Chen, Wang Lei
Abstract excerpt
Family with sequence similarity 20C (Fam20C), the major protein kinase in the secretory pathway, generates the vast majority of the secreted phosphoproteome. However, the regulatory mechanisms of Fam20C transport, secretion, and function remain largely unexplored. Here, we show that Fam20C exists as a type II transmembrane protein within the secretory compartments, with its N-terminal signal peptide-like region...
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