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Lysosomes and Cancer Progression: A Malignant Liaison

25 Feb 2021

Abstract excerpt

During primary tumorigenesis isolated cancer cells may undergo genetic or epigenetic changes that render them responsive to additional intrinsic or extrinsic cues, so that they enter a transitional state and eventually acquire an aggressive, metastatic phenotype. Among these changes is the alteration of the cell metabolic/catabolic machinery that creates the most permissive conditions for invasion, dissemination,...

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Identifiers

PMID: 33718382
DOI: 10.3389/fcell.2021.642494

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