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Article

TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate

2 Aug 2021

Abstract excerpt

It is critical to understand how human quiescent long-term hematopoietic stem cells (LT-HSCs) sense demand from daily and stress-mediated cues and then transition into bioenergetically active progeny to differentiate and meet these cellular needs. However, the demand-adapted regulatory circuits of these early steps of hematopoiesis are largely unknown. Here we show that lysosomes, sophisticated nutrient-sensing...

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PMID: 34343492
DOI: 10.1016/j.stem.2021.07.003

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