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Article

Partner and localizer of BRCA2 (PALB2) pathogenic variants and ovarian cancer: A systematic review and meta-analysis.

Gynecologic oncology - 1 Oct 2023

Narayan Priyanka, Ahsan Muhammad Danyal, Webster Emily M, Perez Luiza, Levi Sarah R, Harvey Benedict, Wolfe Isabel, Beaumont Shanice, Brewer Jesse T, Siegel Drew, Thomas Charlene, Christos Paul, Hickner Andy, Chapman-Davis Eloise, Cantillo Evelyn, Holcomb Kevin, Sharaf Ravi N, Frey Melissa K

Abstract excerpt

OBJECTIVE: Approximately 20% of ovarian cancers are due to an underlying germline pathogenic variant. While pathogenic variants in several genes have been well-established in the development of hereditary ovarian cancer (e.g. BRCA1/2, RAD51C, RAD51D, BRIP1, mismatch repair genes), the role of partner and localizer of BRCA2 (PALB2) remains uncertain. We sought to utilize meta-analysis to evaluate the association...

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Share to BRCA2 Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 37651980
DOI: 10.1016/j.ygyno.2023.07.017

Genes

PALB2
BRCA2
BRCA1
BRIP1
RAD51C
RAD51D

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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