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Article

Spectrum and characteristics of germline PALB2 pathogenic variants in 1556 early-onset breast cancer patients in China.

Journal of cancer research and clinical oncology - 25 Jun 2024

Li Jing, He Peng, Cai Qindong, Chen Lili, Wang Yali, Cai Weifeng, Qiu Yibin, Liu Shunyi, Guo Wenhui, Chen Minyan, Lin Yuxiang, Wang Chuan, Fu Fangmeng

Abstract excerpt

PURPOSE: Limited data are available regarding the partner and localizer of BRCA2 (PALB2) in Chinese patients with early breast cancer. This study aimed to assess the spectrum and characteristics of germline PALB2 pathogenic variants in this population. METHODS: Peripheral blood samples were collected from 1556 patients diagnosed with BRCA1/2-negative early-onset breast cancer. All coding regions and exon‒intron...

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Identifiers

PMID: 38914840
DOI: 10.1007/s00432-024-05758-7
PMCID: PMC11196361

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