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Article

PALB2 germline mutations in a large cohort of Middle Eastern breast-ovarian cancer patients.

Scientific reports - 11 May 2023

Siraj Abdul K, Bu Rong, Parvathareddy Sandeep Kumar, Iqbal Kaleem, Azam Saud, Qadri Zeeshan, Al-Rasheed Maha, Haqawi Wael, Diaz Mark, Victoria Ingrid G, Al-Badawi Ismail A, Tulbah Asma, Al-Dayel Fouad, Ajarim Dahish, Al-Kuraya Khawla S

Abstract excerpt

The PALB2 gene is a breast cancer (BC) and ovarian cancer (OC) predisposition gene involved in the homologous recombination repair pathway. However, the prevalence and clinicopathological association of PALB2 pathogenic/likely pathogenic (PV/LPV) variants in Middle East is still not fully explored. Total 918 BC/OC patients from Saudi Arabia were selected for PALB2 mutations screening using capture sequencing...

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Identifiers

PMID: 37169825
DOI: 10.1038/s41598-023-34693-9
PMCID: PMC10175539

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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