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Article

Probability of detecting germline BRCA1/2 pathogenic variants in histological subtypes of ovarian carcinoma. A meta-analysis.

Gynecologic oncology - 1 Jan 2022

Witjes Vera M, van Bommel Majke H D, Ligtenberg Marjolijn J L, Vos Janet R, Mourits Marian J E, Ausems Margreet G E M, de Hullu Joanne A, Bosse Tjalling, Hoogerbrugge Nicoline

Abstract excerpt

BACKGROUND: Histology restricted genetic predisposition testing of ovarian carcinoma patients is a topic of debate as the prevalence of BRCA1/2 pathogenic variants (PVs) in various histological subtypes is ambiguous. Our primary aim was to investigate the proportion of germline BRCA1/2 PVs per histological subtype. Additionally, we evaluated (i) proportion of somatic BRCA1/2 PVs and (ii) proportion of germline...

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PMID: 34702566
DOI: 10.1016/j.ygyno.2021.10.072

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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