Meta-Analysis of Breast Cancer Risk for Individuals with PALB2 Pathogenic Variants

Abstract excerpt

<h4>Background</h4> Pathogenic variants in cancer susceptibility genes can now be tested efficiently and economically with the wide availability of multi-gene panel testing. This has resulted in an unprecedented rate of identifying individuals carrying pathogenic variants. These carriers need to be counselled about their future cancer risk conferred by the specific gene mutation. An important cancer susceptibilit...

Topics

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• Bayes Theorem
• Breast Neoplasms
• Fanconi Anemia Complementation Group N Protein
• Genetic Predisposition to Disease
• Mutation
• Nuclear Proteins
• Odds Ratio
• Risk Factors

Identifiers and source

Literature Corpus work

0c436924-e3e9-51d5-b196-88042c14047f

DOI

10.1101/2023.05.31.23290791