Article
Two PALB2 germline mutations found in both BRCA1+ and BRCAx familial breast cancer.
Breast cancer research and treatment - 1 May 2015
Downs Bradley, Kim Yeong C, Xiao Fengxia, Snyder Carrie, Chen Peixian, Fleissner Elizabeth A, Becirovic Dina, Wen Hongxiu, Sherman Simon, Cowan Kenneth H, Lynch Henry T, Wang San Ming
Abstract excerpt
Partner and localizer of BRCA2 (PALB2), plays an important functional role in DNA damage repair. Recent studies indicate that germline mutations in PALB2 predispose individuals to a high risk of developing familial breast cancer. Therefore, comprehensive identification of PALB2 germline mutations is potentially important for understanding their roles in tumorigenesis and for testing their potential utility as...
Topics
- BRCA1 Protein
- BRCA2 Protein
- Breast Neoplasms
- Fanconi Anemia Complementation Group N Protein
- Female
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Humans
- Male
- Nuclear Proteins