Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer.

doi:10.1093/jnci/djv214

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Article

Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer.

Journal of the National Cancer Institute - 1 Nov 2015

Ramus Susan J, Song Honglin, Dicks Ed, Tyrer Jonathan P, Rosenthal Adam N, Intermaggio Maria P, Fraser Lindsay, Gentry-Maharaj Aleksandra, Hayward Jane, Philpott Susan, Anderson Christopher, Edlund Christopher K, Conti David, Harrington Patricia, Barrowdale Daniel, Bowtell David D, Alsop Kathryn, Mitchell Gillian, Cicek Mine S, Cunningham Julie M, Fridley Brooke L, Alsop Jennifer, Jimenez-Linan Mercedes, Poblete Samantha, Lele Shashi, Sucheston-Campbell Lara, Moysich Kirsten B, Sieh Weiva, McGuire Valerie, Lester Jenny, Bogdanova Natalia, Dürst Matthias, Hillemanns Peter, Odunsi Kunle, Whittemore Alice S, Karlan Beth Y, Dörk Thilo, Goode Ellen L, Menon Usha, Jacobs Ian J, Antoniou Antonis C, Pharoah Paul D P, Gayther Simon A

Abstract excerpt

BACKGROUND: Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy, responsible for 13 000 deaths per year in the United States. Risk prediction based on identifying germline mutations in ovarian cancer susceptibility genes could have a clinically significant impact on reducing disease mortality. METHODS: Next generation sequencing was used to identify germline mutations in the coding regions...

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Identifiers

PMID: 26315354
DOI: 10.1093/jnci/djv214
PMCID: PMC4643629

Genes

BRIP1
BARD1
PALB2
NBN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer.PMID 26315354Read ↗

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