Pathogenic germline variants in non-BRCA1/2 homologous recombination genes in ovarian cancer: Analysis of tumor phenotype and survival.

doi:10.1016/j.ygyno.2023.11.019

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Pathogenic germline variants in non-BRCA1/2 homologous recombination genes in ovarian cancer: Analysis of tumor phenotype and survival.

Gynecologic oncology - 1 Jan 2024

Kahn Ryan M, Selenica Pier, Boerner Thomas, Roche Kara Long, Xiao Yonghong, Sia Tiffany Y, Maio Anna, Kemel Yelena, Sheehan Margaret, Salo-Mullen Erin, Breen Kelsey E, Zhou Qin, Iasonos Alexia, Grisham Rachel N, O'Cearbhaill Roisin E, Chi Dennis S, Berger Michael F, Kundra Ritika, Schultz Nikolaus, Ellenson Lora H, Stadler Zsofia K, Offit Kenneth, Mandelker Diana, Aghajanian Carol, Zamarin Dmitriy, Sabbatini Paul, Weigelt Britta, Liu Ying L

Abstract excerpt

OBJECTIVE: To define molecular features of ovarian cancer (OC) with germline pathogenic variants (PVs) in non-BRCA homologous recombination (HR) genes and analyze survival compared to BRCA1/2 and wildtype (WT) OC. METHODS: We included patients with OC undergoing tumor-normal sequencing (MSK-IMPACT) from 07/01/2015-12/31/2020, including germline assessment of BRCA1/2 and other HR genes ATM, BARD1, BRIP1, FANCA,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to BRCA2 Protein

Share to Genetic Predisposition to Disease

Share to Germ Cells

Share to Germ-Line Mutation

Share to Homologous Recombination

Share to Ovarian Neoplasms

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 38041901
DOI: 10.1016/j.ygyno.2023.11.019
PMCID: PMC10922242

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pathogenic germline variants in non-BRCA1/2 homologous recombination genes in ovarian cancer: Analysis of tumor phenotype and survival.PMID 38041901Read ↗

Prevalence and outcomes of germline pathogenic variants of homologous recombination repair genes in ovarian cancer.Semantic proximity Read ↗

Homologous Recombination Deficiency in Ovarian and Breast Cancers: Biomarkers, Diagnosis, and TreatmentSemantic proximity Read ↗

Germline and somatic mutations in homologous recombination genes predict platinum response and survival in ovarian, fallopian tube, and peritoneal carcinomas.Semantic proximity Read ↗

The clinical pathological characteristics and prognostic Relevance of Homologous Recombination Repair Gene Mutations in Ovarian Cancer Patients：A Retrospective Cohort StudySemantic proximity Read ↗

Clinical characteristics of ovarian cancer classified by BRCA1, BRCA2, and RAD51C status.Semantic proximity Read ↗

Homologous Recombination Deficiency: Cancer Predispositions and Treatment Implications.Semantic proximity Read ↗

Validation of Genomic and Transcriptomic Models of Homologous Recombination Deficiency in a Real-World Pan-Cancer CohortSemantic proximity Read ↗

Moderate-Risk Genes for Hereditary Ovarian Cancers Involved in the Homologous Recombination Repair Pathway.Semantic proximity Read ↗

Prevalence of Homologous Recombination–Related Gene Mutations Across Multiple Cancer TypesSemantic proximity Read ↗

Extended panel testing in ovarian cancer reveals BRIP1 as the third most important predisposition gene.Semantic proximity Read ↗

Pan-cancer analysis of bi-allelic alterations in homologous recombination DNA repair genesSemantic proximity Read ↗

Pan-cancer landscape of homologous recombination deficiency.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.